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Metabolic Syndrome and Weight Gain


The American Heart Association recommends that health care professionals “routinely monitor body weight (especially the index for central obesity), blood glucose, lipoproteins and blood pressure; treat individuals' risk factors ... and carefully choose anti-hypertensive drugs because different agents have different effects on insulin sensitivity."
American Heart Association - Metabolic Syndrome
A root cause of obesity is Insulin Resistance, which, in turn, is a key factor in the development of Metabolic Syndrome, a major source of damage to your cardiovascular system which is also known as Syndrome X.

Reversing Insulin Resistance can be a crucial factor in heart disease prevention because it is a direct link to the weight gain so often seen in men and women with Metabolic Syndrome. Insulin is the hormone responsible for allowing glucose, or blood sugar, to be absorbed by the cells of the body, where it is converted to energy. If you are Insulin Resistant, your cells react sluggishly to insulin. When you eat a meal, whether it’s steak, fish or vegetables, the body breaks it down into a usable energy form – glucose.

Metabolic Syndrome and Weight Gain InformationIn a simplified explanation, the food you consume becomes sugar that will be transported to the tissues, muscles and organs of the body via the blood stream to be converted into energy. Following a meal, particularly one that is high in carbohydrates, you will have elevated levels of glucose in the blood stream, which signal the pancreas to release even more insulin until the excess glucose is absorbed by the cells.

When you are Insulin Resistant, excessive amounts of free-floating glucose remain in the blood stream until they are sent to the liver and converted to excess body fat. In addition, hyperinsulinemia (elevated insulin in the blood) encourages your liver to produce even more triglycerides which are directly related to a greater risk of heart disease.

Heart Disease "Eating fast food more than twice a week may double the risk of developing Insulin Resistance."
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Insulin Resistance promotes fat storage because glucose cannot properly enter the cells to be used as energy. Elevated levels of insulin in the blood stream lead to a series of biochemical reactions with wide-ranging consequences that can lead to a variety of other serious health conditions, such as Cardiovascular Disease, hypertension (high blood pressure), Type 2 Diabetes and some cancers.

The interactions of Insulin Resistance, obesity and Metabolic Syndrome are complex and still under medical review. Many scientists believe that this is a case of "which came first: the chicken or the egg". Insulin Resistance contributes to obesity and is an underlying cause of Metabolic Syndrome, while obesity worsens Insulin Resistance, which then accelerates the development of Metabolic Syndrome. It is likely that each disorder exacerbates the other in a vicious cycle.

Because there is no single solution that addresses all the symptoms of Insulin Resistance or Metabolic Syndrome, you must rely on a multi-faceted approach to reversing these conditions. A complete system is required to address the issues presented by these syndromes – one that includes nutraceuticals (vitamins, herbs and minerals that are disease specific), a realistic exercise program combined with nutritional guidance and a support network that will help you change unhealthy lifestyle choices.

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Overweight Men Face Double Threat From Prostate Cancer





Overweight and obese men run a double risk of developing prostate cancer, according to another new study.

It suggests that a man's weight may "mask" the accuracy of a common test to detect prostate cancer, with researchers warning that doctors could be missing this dangerous cancer in obese men.

Between the years 2001–04, a team at San Antonio's University of Texas Health Science Center studied 2,799 men who were free of prostate cancer. In results released online in the journal Cancer, researchers reported finding that the more obese men were, the lower their levels of prostate-specific antigen or PSA. A man’s PSA of 4.0 or lower usually means no cancer and the study results were surprising because prostate cancer has been shown in previous studies to be more aggressive in obese men than males of average weight. The Texas researchers wanted to discover whether the detection of cancer was somehow being delayed in obese men.

The study found that obese men have PSA levels that are about 30% lower than males of normal weight. "That tells us it’s likely or it’s possible that prostate cancer detection may be delayed in overweight or obese men," said Jacques Baillergeon, Associate Professor of epidemiology at the University of Texas Health Science Center.

It did not explain why obese men have lower PSA levels. But doctors believe obese men produce more estrogen, which drives down testosterone levels and could affect the antigen used in the PSA test.

The research may spur many doctors to take a closer look at the test results of obese male patients. "For sure, I will be more vigilant in my patients, who are obese, in evaluating their PSA," said Dr. Nelson Stone of Mount Sinai School of Medicine in New York City, who was not involved in the study.

Dr Stone added that colleagues might be losing some of the PSA test’s sensitivity, reducing its ability to detect prostate cancer in obese patients. "We may have to set our sights lower," he said.

The antigen used in the PSA test is made by normal prostate cells and is measured in blood. The higher the antigen level, the more likely the chance of prostate cancer, according to the American Cancer Society. But having a high PSA level is not a definitive diagnosis of cancer, which is why the Atlanta-based Society recommends that men with high PSA levels should have a biopsy.

The Texas study builds on previous research released in May last year in the New England Journal of Medicine which found that 15% of men with a "normal" PSA actually had prostate cancer and that two-thirds of those men had aggressive cases.

Many people are unaware that they are suffering from Metabolic Syndrome, even though the American Heart Association estimates that 20–25% of the adult population of the U.S. have this disorder – between 58 and 73 million men and women.

Metabolic Syndrome is characterized by having at least three of the following symptoms:
  • Insulin Resistance (when the body can’t absorb blood sugar or insulin properly)
  • Abdominal fat – in men this means a 40 inch waist or larger, in women 35 inches or larger
  • High blood sugar levels – at least 110 milligrams per deciliter (mg/dL) after fasting
  • High triglycerides – at least 150 mg/dL in the blood stream
  • Low HDL (the "good" cholesterol) – less than 40 mg/dL
  • Prothrombotic state (a precursor of Cardiovascular Disease)
  • Blood pressure of 130/85 mmHg or higher

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"Researchers agree that insulin resistance is central to the metabolic syndrome. When target cells are unresponsive to insulin, the pancreas responds by pouring even more insulin into the bloodstream, leading to high levels of the hormone in the blood, a condition called compensatory hyperinsulinemia. The high level of insulin in the blood forces glucose into cells but also starts the events leading to arterial damage and eventually a heart attack. Under these conditions, a person may not manifest either diabetes or heart disease but could well be on the way to either or both."
A. MAUREEN ROUHI, Chemical and Engineering News. November 22, 2004.Vol. 82, No.47  
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"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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"A non-pharmacologic treatment for these patients is needed, since drugs prescribed to lower blood pressure have been shown to actually worsen carbohydrate and lipid metabolism in Syndrome X patients, negating the beneficial effects of those drugs."
Duke University Study, results published in the Archives of Internal Medicine, September 2003.
Article by Dr. Sheri Colberg, Phd, FACSM
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"I cannot believe the difference the Insulite System has made in how I feel. My appetite has changed tremendously. I do not crave carbs and sugar and my appetite is somewhat diminished."
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"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
"To gain the most benefit from modifying multiple metabolic risk factors, the underlying insulin-resistant state must become a target of therapy."
Bogdanovic, Streten and Langlans, Beata, "Metabolic Syndrome: New Opportunities in Diagnostics and Therapeutics", DMD Publications, 2004.  
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